Spanish-American Professor of Neurology at Harvard Medical School. He is currently a Senior Scientist at the Hinda and Arthur Marcus Institute for Aging Research at Hebrew Senior Life.
Pascual-Leone is a world leader in developing transcranial magnetic stimulation for application in cognitive neuroscience and for therapeutic applications in neurology, psychiatry and neurorehabilitation. Pascual-Leone’s research projects aim at understanding the mechanisms that control brain plasticity across the lifespan to be able to modify them for the subject’s optimal behavioral outcome. Pascual-Leone combines various brain imaging and brain stimulation methodologies to establish a causal relationship and precise chronometry between regional brain activation and behavior and uses noninvasive brain stimulation techniques to modulate brain plasticity, suppressing some changes and enhancing others to gain a clinical benefit and behavioral advantage for a given individual. Such non-invasive approaches can lead to clinically relevant therapeutic effects in neuropsychiatry and neurorehabilitation and serve as proof-of-principle before more invasive neuromodulatory interventions.
Director of the Center for Noninvasive Brain Stimulation based in Barcelona. This Brain Health center is a multi-year longitudinal effort supported by La Caixa and the Guttmann Institute and aims to identify markers of brain health throughout life and develop and test multimodal outbreaks and lifestyle changes that maintain brain health by preventing age-related cognitive decline.